2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0)
Ihe ize ndụ na Nchekwa
| Akara egwu | C - Na-emebi emebi |
| Koodu ihe egwu | 34 – Na-ebute ọkụ |
| Nkọwapụta nchekwa | S26 - N'ihe banyere kọntaktị na anya, kpochaa ozugbo na ọtụtụ mmiri ma chọọ ndụmọdụ ahụike. S36 / 37/39 - Yiri uwe nchebe kwesịrị ekwesị, uwe aka na nchebe anya / ihu. S45 - Ọ bụrụ na ihe mberede ma ọ bụ ọ bụrụ na ahụ adịghị gị mma, chọọ ndụmọdụ ahụike ozugbo (gosi akara ahụ mgbe ọ bụla enwere ike.) S27 - Yipụ uwe niile emeru ozugbo. |
| NJ UN | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| TSCA | Ee |
| Koodu HS | 29335990 |
| Klas Hazard | 8 |
| Otu nkwakọ ngwaahịa | III |
2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0) Ozi
| Jiri | 2, 4-dichloro-5-methylpyrimidine nwere ike iji na nkwadebe nke 2-fluoro-5-trifluoromethylpyrimidine. 2-fluoro-5-trifluoromethylpyrimidine bụ ihe dị mkpa n'etiti maka njikọ nke ọgwụ, nke a pụrụ iji synthesize fused mgbanaka dihydrofuran ogige, na fused mgbanaka dihydrofuran ogige nwere ike iji dị ka G protein tinyere receptor GPR119 modulators, maka ọgwụgwọ nke ọrịa shuga, oke ibu na ọrịa dyslipidemia. Tụkwasị na nke ahụ, a pụkwara iji 2-fluoro-5-trifluoromethylpyrimidine mee ihe dị ka onye na-emekọrịta ihe na nchịkọta ọgwụ maka ọgwụgwọ ọrịa Alzheimer na schizophrenia. |
| nkwadebe | 5-methyluracil 75g (0.59mol), phosphorus oxychloride 236g, triethylamine hydrochloride 16.5g (0.12mol), agbakwunyere na flask mmeghachi omume, kpụ ọkụ n'ọnụ na 100 ℃ ~ 110 ℃, Reflux mmeghachi omume 5H, mma 40 40 ℃ penta chloride. 1.19mol), okpomọkụ mmeghachi omume nchekwa 2H. Mgbe emechara mmeghachi omume ahụ, a na-enweta phosphorus oxychloride site na distillation n'okpuru nrụgide na-ebelata, na distillation n'okpuru nrụgide dị ala nọgidere na-enweta 88g (0.54mol) nke 2, 4-dichloro-5-methylpyrimidine na mkpụrụ nke 91.5%. |
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