2 4-Difluorobenzoic acid (CAS # 1583-58-0)

Ngwa

2, 4-difluorobenzoic acid bụ ọgwụ dị mkpa na pesticide intermediate, dị ka 2, 4-difluorobenzoic acid na-bụ iji synthesize antifungal ọgwụ fluconazole, voriconazole na ọgwụ pesticide intermediate 4-fluorosalicylic acid, ọgwụ etiti 3, 5-difluoroaniline, wdg 2, 4-difluorobenzoic acid nwekwara ike iji na mmiri kristal ihe, nke nwere uru nke uru dị elu na atụmanya ahịa dị mma.

Nkwadebe

Tinye 2, 4-dinitrotoluene na mmiri na arịa mmeghachi omume, gbanwee pH uru na 7, kpalie na okpomọkụ ruo 75 ° C. A na-agbakwunye potassium permanganate, magnesium sulfate na ihe na-enyefe oge na-enyefe oge na batches. Mgbe ịgbakwunye, nọgide na-akpali ma na-emeghachi omume na okpomọkụ mgbe niile maka awa 3. Fichaa mgbe ọ na-ekpo ọkụ ma were mmiri ọkụ na-asa achicha nzacha. Jikọta filtrate, acidify na 35% hydrochloric acid na pH 2-3, e nwere ọnụ ọgụgụ buru ibu nke na-acha ọcha ọcha mgbe kristal na-ekpochapụ kpamkpam, na-ehichapụ, na-asachapụ, recrystallized, na nke a mịrị amị iji nweta kristal ọcha dị ka 2,4-dinitrobenzoic acid. . Oke nke 2, 4-dinitrotoluene na potassium permanganate bụ 2.4: 1. Mkpụrụ ngwaahịa nke nzọụkwụ a bụ 90.7%.

tinye N, N-dimethylphthalamide n'ime akpa mmeghachi omume, kpoo ọkụ na 100 ~ 110 ℃, kpoo ọkụ maka 0.5 ~ 1h. Tinye potassium fluoride a mịrị amị n'okpuru mkpali ma mee ka okpomọkụ dị ọkụ maka 0.5-1h. Mgbe nke ahụ gasịrị, 2, 4-dinitrobenzoic acid na hexyltrimethylammonium bromide na-agbakwunye ngwa ngwa na arịa mmeghachi omume n'otu oge, na kpo oku na-aga n'ihu na 120 ℃, a na-echekwa okpomọkụ na mmeghachi omume na-akpali akpali. Mgbe 7h nke mmeghachi omume reflux gasịrị, a na-enweta ihe mgbaze site na distillation, mgbe ahụ, a na-agbanye mmiri mmiri mmeghachi omume na uzuoku. Iberibe nke anakọtara bụ emulsion ọcha. Mgbe eguzo ruo oge ụfọdụ, mmanu mmanu lekwasịrị nta n'ụzọ bụ isi sinks na ala, na-acha ọcha ọcha mmiri mmiri na elu akụkụ na-mma na-mmalite na-acha ọcha kristal iji nweta crude ngwaahịa; A na-emegharị ngwaahịa ahụ crude, nzacha mmiri, ịsacha, na ihicha iji nweta kristal ọcha nke 2,4-difluorobenzoic acid. Oke nke 2, 4-dinitrobenzoic acid na potassium fluoride bụ 2.7: 1. Mkpụrụ ngwaahịa nke nzọụkwụ a bụ 72.4%.

Okwu mmalite
2,4-Difluorobenzoic acid bụ ngwakọta organic. Ihe na-esonụ bụ mmalite nke Njirimara, ojiji, ụzọ nkwadebe na ozi nchekwa nke 2,4-difluorobenzoic acid:

Ogo:
- Ọdịdị: 2,4-Difluorobenzoic acid bụ ọcha crystalline siri ike.
- Solubility: Ọ bụ soluble na nkịtị organic solvents dị ka ethanol, methanol na methylene chloride.

Jiri:
- Ngwa ngwa anya: A pụkwara iji ya mee ihe dị ka otu n'ime akụrụngwa maka nkwadebe nke ngwa anya na ihe nkiri ihe nkiri.
- Ngwa ụlọ ọrụ: 2,4-difluorobenzoic acid nwere ike iji mee ihe na ụlọ ọrụ eletriki, mkpuchi na ụlọ ọrụ plastik na mgbochi corrosion, mgbochi oxidation na mmetụta ultraviolet.

Usoro:
-2,4-Difluorobenzoic acid nwere ike nweta site fluorination nke hydrofluoric acid na p-methylanisole.

Ozi nchekwa:
- Mgbe ị na-arụ ọrụ, ekwesịrị ịzere uzuzu ka ịzena ikuku ume na ịhụ anya. N'otu oge ahụ, ekwesịrị idobe ọnọdụ ikuku ikuku dị mma.
- Zere ịkpọtụrụ ndị ọrụ oxidizing siri ike ma ọ bụ acid siri ike iji zere mmeghachi omume dị ize ndụ