2,4,5-Trifluorophenylacetic Acid (CAS# 209995-38-0)
Ngwa
2,4, 5-trifluorophenylacetic acid bụ ihe siri ike na-acha ọcha nke a na-eji emepụta ọgwụ ọhụrụ sitagliptin intermediates maka ọgwụgwọ ụdị ọrịa shuga II. sitagliptin bụ ihe mgbochi mbụ DPP-IV nke Merck depụtara ọhụrụ. Ọ nwere mmetụta ọgwụgwọ dị mma, obere mmetụta, ezigbo nchekwa na nnabata na ọgwụgwọ ụdị ọrịa shuga II, ma nwee atụmanya ahịa sara mbara.
Nkọwapụta
Ọdịdị crystallization
Agba Ọcha ka Gbanyụọ-Ọcha
pKa 3.78± 0.10 (buru amụma)
Ọnọdụ Nchekwa Emechiri na nkụ, Okpomọkụ ụlọ
Ntụgharị ntụgharị 1.488
Nchekwa
Ihe akara egwu Xi - iwe
Iwe iwe
Koodu ihe ize ndụ R37/38 - na-akpasu iwe na sistem iku ume na akpụkpọ ahụ.
R41 - ihe ize ndụ nke nnukwu mmebi anya
Nkọwa nchekwa S26 - Ọ bụrụ na ị na-ahụ anya, jiri mmiri buru ibu sachaa ozugbo wee chọọ ndụmọdụ ahụike.
S39 - Yiri anya / nchedo ihu.
WGK Germany 3
Koodu mpaghara:: 29163990
Klas ihe egwu IGBO
Mbukota & Nchekwa
Ajuju na 25kg / 50kg drum. Debe n'ebe gbara ọchịchịrị, mechie ya na nkụ, okpomọkụ ụlọ
Okwu mmalite
Na-ewebata 2,4,5-Trifluorophenylacetic Acid, nke siri ike na-acha ọcha nke a na-ejikarị na ụlọ ọrụ ọgwụ maka ịmepụta sitagliptin intermediates maka ọgwụgwọ ụdị ọrịa shuga II.
Dị ka akụkụ dị mkpa na mmepụta nke sitagliptin, 2,4,5-Trifluorophenylacetic acid arụwo ọrụ dị oke mkpa na mmepe nke ọgwụ a dị oke mma. Sitagliptin bụ ihe mgbochi DPP-IV kachasị ọhụrụ nke Merck depụtara na nso nso a. Ọ na-anya isi mmetụta ọgwụgwọ dị mma, mmetụta dị ntakịrị, nchekwa na ndidi, wee bụrụ ọgwụ na-aga n'ịgwọ ụdị ọrịa shuga II.
Otu n'ime uru dị mkpa nke 2,4,5-Trifluorophenylacetic Acid bụ na ọ na-enyere aka imepụta sitagliptin n'ọnụ ego dị ọnụ ala, na-enye ọtụtụ mmadụ ohere ịnweta ọgwụ a na-agbanwe ndụ. Tụkwasị na nke ahụ, ọ na-arụ ọrụ nke ọma n'ịgwọ ọrịa shuga ma na-enye olileanya ọhụrụ maka ndị na-alụso ọrịa ahụ ọgụ.
Ọdịdị nke 2,4,5-Trifluorophenylacetic Acid bụ kristal na-acha ọcha na-acha ọcha na-acha ọcha, na-eme ka ọ dị mfe ịmata, aka, na ibufe. Ọ dịkwa mma n'okpuru ọnọdụ nkịtị, nke pụtara na enwere ike ịchekwa ya ruo ogologo oge n'emebighị ya.
2,4,5-Trifluorophenylacetic Acid dị ukwuu na enwere ike iji ya na njikọ nke ogige ndị ọzọ dị mgbagwoju anya gafere etiti sitagliptin. Ọ nwere ngwa ụlọ ọrụ dị iche iche, gụnyere mmepụta nke agrochemicals, resins na intermediates. A pụkwara iji ya mee ihe dị ka ihe mmalite maka njikọ nke ụdị ihe dị iche iche nke nwere ngwa dị iche iche.
N'ụlọ ọrụ anyị, anyị na-anya isi na ịnye ndị ahịa anyị 2,4,5-Trifluorophenylacetic acid dị elu. Ngwaahịa anyị na-ezute ụkpụrụ kachasị mma ma arụpụtara ya na-agbaso ntuziaka siri ike iji hụ na ọ na-agbanwe agbanwe na ịdị ọcha.
N'ikpeazụ, 2,4,5-Trifluorophenylacetic acid bụ ihe bara uru nke ukwuu nke ghọrọ akụkụ bara uru na mmepụta nke sitagliptin, ọgwụ mbụ maka ụdị ọrịa shuga II. Ntugharị ya na ịdị irè ya na-eme ka ọ bụrụ ihe bara uru na ụlọ ọrụ ọgwụ na kemịkalụ, anyị na-enwekwa obi ụtọ ịnye ndị ahịa anyị 2,4,5-Trifluorophenylacetic acid dị elu.
