5-Bromo-3-nitro-2-pyridinol (CAS# 15862-34-7)
Ihe ize ndụ na Nchekwa
| Koodu ihe egwu | R22 - na-emerụ ma ọ bụrụ na iloro ya R37 / 38 - na-akpasu iwe na usoro iku ume na akpụkpọ ahụ. R41 - Ihe ize ndụ nke mmebi anya dị njọ R36 / 37/38 - na-akpasu iwe na anya, usoro iku ume na akpụkpọ ahụ. R20 - na-emerụ ahụ site na iku ume |
| Nkọwapụta nchekwa | S26 - N'ihe banyere kọntaktị na anya, kpochaa ozugbo na ọtụtụ mmiri ma chọọ ndụmọdụ ahụike. S36 / 37/39 - Yiri uwe nchebe kwesịrị ekwesị, uwe aka na nchebe anya / ihu. S36 - Yiri uwe nchebe kwesịrị ekwesị. |
| NJ UN | 2811 |
| WGK Germany | 3 |
| Koodu HS | 29337900 |
| Ihe edeturu egwu | Na-emerụ ahụ |
| Klas Hazard | Iwe |
Ozi ntụaka
| Jiri | 5-bromo-2-hydroxy-3-nitropyridine bụ etiti etiti nke enwere ike iji kwadebe ogige 3-amino-1- (2-oxo-2--- (3 '-(trifluoromethyl)) - [1,1'-biphenyl ] -4-yl) ethyl) -5- (pyrrole alkyl-1-yl-sulfonyl) pyridin-2 (1H) -otu, ogige a bụ ihe mgbochi DOCK1. |
| usoro njikọ | nitric acid (60-61%,3.5mL) agbakwunyere na ngwọta (10mL) nke 5-bromopyridine -2 (1H) -otu (1.75g,10.1mmol) na sulfuric acid na 0 ℃. A na-ekwe ka ngwakọta ahụ kpoo ọkụ n'ime ụlọ ma kpalie ya maka awa 3. A na-awụsa ngwakọta mmeghachi omume n'ime mmiri ice na ihe na-esi na ya pụta na-anakọta site na nzacha. A na-asacha ngwaahịa a na-emepụta na mmiri ma kpoo ya na oghere, na-enye 5-bromo-2-hydroxy-3-nitropyridine (960mg, 43% mkpụrụ) dị ka ihe siri ike na-acha ọcha. 1H NMR (500MHz, CDCl3) δ:8.57(s,1H),8.26(s,1H). |
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