5-Fluorocytosine (CAS# 2022-85-7)
Ihe ize ndụ na Nchekwa
| Koodu ihe egwu | R40 - Ihe akaebe dị oke nke mmetụta carcinogenic R36 / 37/38 - na-akpasu iwe na anya, usoro iku ume na akpụkpọ ahụ. R63 - Ihe ize ndụ nwere ike imerụ nwa e bu n'afọ |
| Nkọwapụta nchekwa | S22 - Ekula uzuzu. S24/25 - Zere kọntaktị na akpụkpọ ahụ na anya. S45 - Ọ bụrụ na ihe mberede ma ọ bụ ọ bụrụ na ahụ adịghị gị mma, chọọ ndụmọdụ ahụike ozugbo (gosi akara ahụ mgbe ọ bụla enwere ike.) S36/37 - Yiri uwe nchebe kwesịrị ekwesị na uwe aka. S36 / 37/39 - Yiri uwe nchebe kwesịrị ekwesị, uwe aka na nchebe anya / ihu. S27 - Yipụ uwe niile emeru ozugbo. S26 - N'ihe banyere kọntaktị na anya, kpochaa ozugbo na ọtụtụ mmiri ma chọọ ndụmọdụ ahụike. |
| WGK Germany | 2 |
| RTECS | HA 6040000 |
| FLUKA BRAND F CODES | 10-23 |
| Koodu HS | 29335990 |
| Ihe edeturu egwu | Nsi/Mmetụta Ọkụ |
| Klas Hazard | Iwe, ọkụ Sen |
| Nsi | LD50 n'ime oke (mg/kg):>2000 ọnụ na sc; 1190 ip; 500 iv (Grunberg, 1963) |
5-Fluorocytosine (CAS# 2022-85-7) Okwu mmalite
àgwà
Ngwaahịa a bụ ntụ ntụ kristal na-acha ọcha ma ọ bụ na-acha ọcha, enweghị isi ma ọ bụ ntakịrị ísì. Obere soluble na mmiri, solubility nke 1.2% na 20 Celsius C na mmiri, ntakịrị soluble na ethanol; Ọ fọrọ nke nta ka ọ ghara ịsacha ya na chloroform na ether; Soluble na itughari hydrochloric acid ma ọ bụ itughari sodium hydroxide ngwọta. Ọ kwụsiri ike na ụlọ okpomọkụ, na-ebuli kristal mgbe oyi na-atụ, na obere akụkụ na-agbanwe na 5-fluorouracil mgbe ọ na-ekpo ọkụ.
Ngwaahịa a bụ ọgwụ antifungal arụpụtara na 1957 ma jiri ya mee ihe na ụlọ ọgwụ na 1969, yana mmetụta antibacterial doro anya na Candida, cryptococcus, fungi agba na Aspergillus, na enweghị mmetụta mgbochi na fungi ndị ọzọ.
Mmetụta mgbochi ya na fungi bụ n'ihi ịbanye na sel nke fungi nwere mmetụta, ebe n'okpuru ọrụ nke nucleopyine deaminase, na-ewepụ otu amino dị iche iche iji mepụta antimetabolite-5-fluorouracil. Nke ikpeazụ na-agbanwe ghọọ 5-fluorouracil deoxynucleoside ma na-egbochi thymine nucleoside synthetase, na-egbochi ntughari nke uracil deoxynucleoside n'ime thymine nucleoside, na-emetụta DNA njikọ.
jiri
Antifungals. A na-ejikarị ya eme ihe maka candidiasis mucocutaneous, candiddal endocarditis, ọrịa ogbu na nkwonkwo, cryptococcal meningitis na chromomycosis.
Ojiji na onunu ogwu Oral, 4 ~ 6g kwa ụbọchị, kewara 4 ugboro.
nche
Ekwesịrị ịlele ọnụọgụ ọbara mgbe niile n'oge nchịkwa. Ndị na-arịa ọrịa imeju na akụrụ na-arịa ọrịa ọbara na ụmụ nwanyị dị ime kwesịrị iji nlezianya mee ihe; Contraindicated na ndị ọrịa nwere nnukwu ụkọ gbasara akụrụ.
Shading, nchekwa ikuku.
