dabigatran etexilate (CAS# 211915-06-9)

Ngwongwo kemịkalụ:

Usoro ihe omimi	C34H41N7O5
Molar Mass	627.73
Njupụta	1.24± 0.1 g/cm3 (buru amụma)
Ebe Na-agbaze	128-129°
Ebe Boling	827.9°C na 760 mmHg
Ebe mgbari	454.5C
Solubility	DMSO (obere), methanol (obere)
Uzuoku nrịbama	1.49E-27mmHg na 25°C
Ọdịdị	siri ike
Agba	Ọcha na-acha odo odo
pKa	9.88± 0.46 (buru amụma)
Ọnọdụ Nchekwa	E mechiri ya na nkụ, chekwaa na friza, n'okpuru -20 Celsius
Nkwụsi ike	Hygroscopic
Ntụgharị uche	1.614
Ọmụmụ in vitro	Dabigatran na-ahọrọ na ngbanwe na-egbochi thrombin mmadụ (Ki: 4.5 nM) na nchịkọta platelet na-ebute thrombin (IC50: 10 nM) na enweghị mmetụta mgbochi na ihe ndị ọzọ na-akpali akpali platelet. Dabigatran na-egbochi ọgbọ nke thrombin (PPP) na plasma nke platelet mebiri emebi na IC50 nke 0.56 μm dị ka atụpụtara site na Index thrombin Index (ETP). Nnwale in vitro, Dabigatran nwere mmetụta anticoagulant dabere na ntinye uche na ụdị dị iche iche. N'ime mmadụ PPP, oge thromboplastin na-arụ ọrụ (aPTT), oge prothrombin (PT) gbagoro okpukpu abụọ na ntinye nke 0.23,0.83 na 0.18 μm, n'otu n'otu. Na Ecarin clotting oge (ECT).
Na vivo ọmụmụ	Dabigatran dose na-adabere na APPT ogologo oge mgbe nchịkwa eriri afọ na oke (0.3,1 na 3 mg / kg) na enwe rhesus (0.15,0.3 na 0.6 mg / kg). Dabigatran etexilate (20 mg / kg, PO) na-emepụta obere ogologo oge nke k uru na obere mbelata nke mmụba kachasị na ezì karịa enoxaparin. Dabigatran (0.01-0.1 mg / kg) dose-dabere na-ebelata thrombosis, yana ED50 (50% dị irè dose) bụ 0.033 mg / kg na mgbochi zuru oke na 0.1 mg / kg. Dabigatran etexilate (5-30 mg / kg) na-egbochi mmepụta thrombus n'ụdị dose na oge dabere, yana mgbochi kachasị na-eme mgbe 30 min tupu ọgwụgwọ, na-egosi mmetụta na-eme ngwa ngwa.

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Nkọwa ngwaahịa

Mkpado ngwaahịa

Okwu mmalite

Dibutyl phthalate bụ ngwakọta organic. Ọ bụ mmiri mmiri na-acha odo odo na-enweghị agba na-esi ísì ụtọ.

A na-ejikarị Dabigatran etexilate eme ihe dị ka plasticizer. Ọ nwere ike ịkwalite ịdị nro na ductility nke rọba, ya mere a na-eji ya eme ihe n'ịmepụta ngwaahịa plastik, dị ka ihe nkiri plastik, ọkpọkọ plastik, ala plastik na akpụkpọ ụkwụ plastik. Enwere ike iji ya dị ka ihe mgbakwunye na ihe mgbaze, lubricants na fragrances.

A na-akwadokarị Dabigatran etexilate site n'iwepụta phthalic anhydride na n-butanol ma ọ bụ isobutanol. A na-emekarị mmeghachi omume n'ihu onye na-emepụta acid na okpomọkụ kwesịrị ekwesị na nrụgide.

Ọ nwere ike ịkpasu akpụkpọ ahụ na anya iwe, a ga-ejikwa mmiri dị ukwuu sachaa ya ozugbo emechara ya. Zere imeghachi omume na oxidants, na-ezere isi mmalite ọkụ na pụọ na oke okpomọkụ na ọkụ na-emeghe n'oge ọrụ na nchekwa. Ekwesịrị ịgbanye ya nke ọma mgbe a na-eji ya ka ọ ghara ịchịkọta uzuoku.

Nke gara aga: 2-(4-BROMOPHENYL)PROPAN-2-OL (CAS# 2077-19-2)

Osote: 4-Methyl hydrogen L-aspartate (CAS # 2177-62-0)

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