Ethyl 1- (4-methoxyphenyl) -6- (4-aminophenyl) -7-oxo-4 5 6 7-tetrahydro-1H-pyrazolo [3 4-c] pyridine-3-carboxylate (CAS # 503615-07-4) )

Okwu mmalite

Ihe na-esonụ bụ mmalite nke akụrụngwa, ojiji, ụzọ nkwadebe na ozi nchekwa nke apixaban intermediate 3:

Ogo:

Apixaban intermediate 3 bụ ngwakọta organic. Ọ siri ike na soluble na organic solvents dị ka ether na ethyl acetate.

Na-eji: A na-ejikarị ya eme ihe maka ịwa ahụ na ọgwụgwọ nke oke mgbu.

Usoro:

Enwere ike ịme usoro nkwadebe nke apixaban etiti 3 site na usoro ndị a: p-nitrobenzoic acid na-emeghachi omume na hypobutylthiourea na ọnụnọ acetic acid na thionyl chloride iji nweta N- (p-nitrophenyl) -N- (hypobutylthioylurea) formic acid, wee meghachi omume na sodium hydroxide na sodium oxide na methanol ngwọta iji nweta apixaban. etiti 3.

Ozi nchekwa: Ekwesịrị ịgbaso usoro ọrụ nchekwa siri ike mgbe ị na-eji yana njikwa ngwa a. Mmekọrịta ozugbo ma ọ bụ iku ume nwere ike imerụ ahụ ike mmadụ nnukwu nsogbu. Ekwesịrị inyocha ma hazie ozi nchekwa ya akọwapụtara dịka iwu na ụkpụrụ dị mkpa iji hụ na ojiji na njikwa adịghị mma. Mgbe ị na-eme nnwale njikọ kemịkalụ, a ga-arụ ya n'okpuru ọnọdụ ụlọ nyocha kwesịrị ekwesị yana akụrụngwa nchedo onwe onye dị ka goggles kemịkalụ, uwe mkpuchi na uwe nchebe kwesịrị iji.