fmoc-O-tert-butyl-D-tyrosine (CAS# 118488-18-9)

Fmoc-O-tert-butyl-D-tyrosine bụ amino acid echekwara echekwabara. Nke a bụ nkọwa nke ọdịdị ya, ojiji ya, nhazi ya na ozi nchekwa:

Ọdịdị:
Fmoc-O-tert-butyl-D-tyrosine bụ kristal ọcha siri ike. Ọ bụ ngwakọta organic nwere usoro kemịkalụ C30H31NO7 yana ịdị arọ nke 521.57g/mol. Ngwakọta ahụ bụ ihe nrụpụta nke tyrosine nke amino group na-ebu otu Fmoc (9-fluorofluorenylformyl) na-echebe otu carboxylic acid na O-tert-butyl.

Jiri:
A na-ejikarị Fmoc-O-tert-butyl-D-tyrosine eme ihe dị ka amino acid echedoro na njikọ peptide. Site na ijikọ otu nchekwa Fmoc na otu amino, enwere ike igbochi mmeghachi omume akụkụ achọghị n'oge njikọ ahụ. A na-eji ya eme ihe n'ọtụtụ ebe na nhazi usoro siri ike ma enwere ike iji ya mee polypeptides na protein.

Ụzọ nkwadebe:
A na-eme nkwadebe nke Fmoc-O-tert-butyl-D-tyrosine site na njikọ kemịkalụ. Nke mbụ, tyrosine na-emeghachi omume na Fmoc-Cl (9-fluorofluorenylcarbonyl chloride) iji mepụta Fmoc-O-tyrosine. A na-agbakwunye Cesium tert-butyl bromide na mmeghachi omume iji mee ka otu carboxylic acid mepụta Fmoc-O-tert-butyl-D-tyrosine. N'ikpeazụ, a na-enweta ngwaahịa dị ọcha site na nzọụkwụ nke crystallization, ịsacha na ihicha.

Ozi nchekwa:
Fmoc-O-tert-butyl-D-tyrosine bụ ogige kwụsiri ike n'okpuru ọnọdụ nkịtị na enweghị mgbanwe doro anya na okpomọkụ ụlọ. Mgbe a na-eji ya eme ihe, ọ dị mkpa ịgbaso usoro nchekwa ụlọ nyocha, yikwasị akụrụngwa nchebe kwesịrị ekwesị, ma zere kọntaktị na akpụkpọ ahụ na anya. Mgbe a na-ejizi ma ọ bụ na-echekwa ya, ekwesịrị idowe ya n'ebe kpọrọ nkụ, dị jụụ ma pụọ ​​​​na ọkụ na ihe ndị na-ekpo ọkụ. N'otu oge ahụ, kọntaktị na oxidants siri ike na acid siri ike kwesịrị izere iji gbochie mmeghachi omume dị ize ndụ. Chọọ enyemaka ahụike ozugbo ma ọ bụrụ na ịtinye ya ma ọ bụ ikpughe na mberede na ogige ahụ.