L-Pyroglutamic acid CAS 98-79-3
Ihe ize ndụ na Nchekwa
| Akara egwu | Xi - mgbakasị ahụ |
| Koodu ihe egwu | 36/37/38 - na-akpasu iwe na anya, usoro iku ume na akpụkpọ ahụ. |
| Nkọwapụta nchekwa | S26 - N'ihe banyere kọntaktị na anya, kpochaa ozugbo na ọtụtụ mmiri ma chọọ ndụmọdụ ahụike. S36 - Yiri uwe nchebe kwesịrị ekwesị. S37/39 - Yiri uwe aka kwesịrị ekwesị na nchebe anya / ihu |
| WGK Germany | 3 |
| RTECS | TW3710000 |
| FLUKA BRAND F CODES | 21 |
| TSCA | Ee |
| Koodu HS | 29337900 |
| Okwu mmalite | pyroglutamic acid bụ 5-oxyproline. A na-emepụta ya site na akpịrị ịkpọ nkụ n'etiti otu α-NH2 na γ-hydroxyl otu glutamic acid iji mepụta njikọ lactam molecular; Enwere ike ịmepụta ya site na ịhapụ otu Amido na molecule glutamine. Ọ bụrụ na glutathione synthetase erughi, nwere ike ịkpata pyroglutamemia, usoro nke mgbaàmà ụlọ ọgwụ. Pyroglutamemia bụ nsogbu nke metabolism organic acid nke kpatara ụkọ glutathione synthetase. Ngosipụta ụlọ ọgwụ nke ọmụmụ 12 ~ 24 awa mmalite, hemolysis na-aga n'ihu, jaundice, Metabolic Acidosis na-adịghị ala ala, nsogbu uche, wdg; Urine nwere pyroglutamic acid, lactic acid, Alpha deoxy4 glycoloacetic acid lipid. Ọgwụgwọ, symptomatic, ṅaa ntị iji dozie nri mgbe afọ gasịrị. |
| Njirimara | L-pyroglutamic acid, nke a makwaara dị ka L-pyroglutamic acid, L-pyroglutamic acid. Site na ngwakọta ethanol na mmanụ ala ether na mmiri ozuzo nke enweghị agba orthorhombic okpukpu abụọ cone Crystal, ebe agbaze nke 162 ~ 163 ℃. Soluble na mmiri, mmanya, acetone na acetic acid, ethyl acetate-soluble, insoluble na ether. Specific ngwa anya ntụgharị -11.9 Celsius (c = 2,H2O). |
| Atụmatụ na ojiji | N'ime akpụkpọ ahụ mmadụ nwere ọrụ moisturize nke ihe soluble mmiri - ihe na-eme ka mmiri dị n'okike, ihe mejupụtara ya bụ amino acid (nwere 40%), pyroglutamic acid (nwere 12%), nnu inorganic (Na, K, Ca, Mg, wdg). nwere 18.5%), na ogige ndị ọzọ organic (nwere 29.5%). Ya mere, pyroglutamic acid bụ otu n'ime ihe ndị bụ isi na-eme ka anụ ahụ na-eme ka anụ ahụ dị nro, na ikike ime mmiri ya karịrị nke glycerol na propylene glycol. Na nke na-adịghị egbu egbu, enweghị mkpali, bụ nlekọta anụ ahụ nke oge a, ihe ịchọ mma nlekọta ntutu isi magburu onwe ya. Pyroglutamic acid nwekwara mmetụta mgbochi na ọrụ tyrosine oxidase, si otú a na-egbochi ntinye nke ihe "melanoid" na akpụkpọ ahụ, nke nwere mmetụta na-acha ọcha na akpụkpọ ahụ. Nwere mmetụta dị nro na akpụkpọ ahụ, enwere ike iji ya mee ihe ịchọ mma ntu. Na mgbakwunye na ngwa na ihe ịchọ mma, L-pyroglutamic acid nwekwara ike ịmepụta ihe ndị na-emepụta ihe na ihe ndị ọzọ na-emepụta ihe, nke nwere mmetụta pụrụ iche na ọrụ elu, nke na-egbuke egbuke ma na-egbuke egbuke, wdg. Chemical reagents maka mkpebi nke amine agbụrụ; Organic intermediates. |
| usoro nkwadebe | A na-emepụta L-pyroglutamic acid site n'iwepụ otu nkeji mmiri site na molekul L-glutamic acid, na usoro nkwadebe ya dị mfe, usoro ndị bụ isi bụ njikwa okpomọkụ na oge nkwụsịtụ. (1) A na-etinye 500g L-glutamic acid na beaker 100 ml, na beaker na-ekpo ọkụ na mmanụ bat, a na-ebulikwa okpomọkụ ruo 145 ruo 150 Celsius C., a na-echekwa okpomọkụ maka nkeji 45 maka akpịrị ịkpọ nkụ. mmeghachi omume. Ihe ngwọta akpọnwụwo nkụ bụ Tan. (2) mgbe emechara mmeghachi omume akpịrị ịkpọ nkụ, a na-awụsa ihe ngwọta ahụ n'ime mmiri na-esi ísì ụtọ na ihe dị ka 350, na ngwọta na-agbaze kpamkpam na mmiri. Mgbe ọ dị jụụ na 40 ruo 50 Celsius C., a na-agbakwunye carbon carbon arụ ọrụ kwesịrị ekwesị maka decoloration (na-emegharị ugboro abụọ). Enwetara ihe ngwọta na-enweghị agba. (3) mgbe a na-ekpo ọkụ na-ekpo ọkụ na-enweghị agba nke edoziri na nzọụkwụ (2) ozugbo wee wepụ ya iji belata olu ruo ihe dị ka ọkara, tụgharịa gaa na mmiri ịsa ahụ ma nọgide na-etinye uche na olu nke ihe dịka 1/3, ị nwere ike ịkwụsị ikpo ọkụ, na n'ime mmiri ọkụ na-ekpo ọkụ iji mee ka kristal ahụ kwụsịlata, awa 10 ruo 20 mgbe nkwadebe nke kristal prismatic na-enweghị agba. Ọnụ ego L-pyroglutamic acid na ịchọ mma na-adabere na nhazi ahụ. A pụkwara iji ngwaahịa a na ihe ịchọ mma n'ụdị ngwọta 50% na-etinye uche. |
| glutamic acid | glutamic acid bụ amino acid mebere protein, nwere eriri akụkụ acidic ionized, ma gosipụta hydrotropism. Glutamic acid na-enwe ike ịbanye na cyclization n'ime pyrrolidone carboxylic acid, I .e., pyroglutamic acid. Acid glutamic dị elu karịa na protein cereal niile, na-enye alfa-ketoglutarate site na okirikiri tricarboxylic acid. Enwere ike ịmepụta alfa ketoglutaric acid ozugbo site na amonia n'okpuru catalysis nke glutamate dehydrogenase na NADPH (coenzyme II), yana aspartate aminotransferase ma ọ bụ alanine aminotransferase nwere ike ime ka glutamic acid na-emepụta site na transamination nke aspartic acid ma ọ bụ alanine; Na mgbakwunye, glutamic acid nwere ike gbanwee ya na proline na ornithine (site na arginine), n'otu n'otu. Ya mere, glutamate bụ amino acid na-adịghị mkpa. Mgbe glutamic acid na-emebi emebi n'okpuru catalysis nke glutamate dehydrogenase na NAD (coenzyme I) ma ọ bụ bufee ya na amino Group n'okpuru catalysis nke aspartate aminotransferase ma ọ bụ alanine aminotransferase iji mepụta alfa ketoglutarate, ọ na-abanye na okirikiri tricarboxylic acid wee mepụta shuga site na ya. ụzọ gluconeogenic, yabụ glutamic acid bụ amino acid glycogenic dị mkpa. glutamic acid n'ime anụ ahụ dị iche iche (dịka akwara, imeju, ụbụrụ, wdg) nwere ike ijikọ glutamine na NH3 site na catalysis nke glutamine synthetase, ọ bụ ngwaahịa detoxification nke amonia, ọkachasị na ụbụrụ ụbụrụ, yana ụdị nchekwa na itinye n'ọrụ. amonia n'ime ahụ (lee "glutamine na metabolism ya"). A na-ejikọta glutamic acid na acetyl-CoA dị ka onye na-akwado mitochondrial carbamoyl phosphate synthase (nke na-etinye aka na njikọ nke urea) site na catalysis nke acetyl-glutamate synthase. γ-aminobutyric acid (GABA) bụ ngwaahịa sitere na decarboxylation nke glutamic acid, ọkachasị n'ọkwa dị elu na anụ ahụ ụbụrụ, ma na-apụtakwa n'ọbara, a na-ahụta ọrụ physiological ya dị ka neurotransmitter inhibitory, antispasmodic na hypnotic mmetụta. Enwere ike nweta infusion nke echinocandin site na GABA. Catabolism nke GABA na-abanye na okirikiri tricarboxylic acid site n'ịgbanwe GABA transaminase na aldehyde dehydrogenase n'ime acid succinic iji mepụta GABA shunt. |
| Jiri | eji dị ka intermediates na organic synthesis, nri mgbakwunye, wdg. eji na nri, ọgwụ, ihe ntecha na ụlọ ọrụ ndị ọzọ |
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