Methyl 2-cyanoisonicotinate (CAS# 94413-64-6)
Ihe ize ndụ na Nchekwa
| Klas Hazard | 6.1 |
Usoro mmepụta
A kwadebere ogige ezubere iche site na oxidation, amidation na akpịrị ịkpọ nkụ na methyl 2-methyl 4-pyridinecarboxylate (2) dị ka ihe mmalite. 1H NMR na MS kwadoro nhazi ya, na mkpokọta mkpụrụ bụ 53.0%. A na-enyocha mmetụta nke nri nri, okpomọkụ crystallization, oge mmeghachi omume na ihe ndị ọzọ dị na ngwaahịa ahụ site na nyocha nke otu ihe, na usoro nhazi usoro bụ kachasị: n (2): n (potassium permanganate) = 1.0: 2.5, crystallization okpomọkụ 0. ~ 5 ℃; n (methyl 2-carboxyl -4-pyridinecarboxylate): n (sulfoxide) = 1.0: 1.4, mmeghachi omume; mmeghachi omume akpịrị ịkpọ nkụ na-ahọrọ usoro trifluoroacetic anhydride-trietylamine dị ka onye na-eme ka mmiri na-ekpo ọkụ. Usoro dị mfe iji rụọ ọrụ, ọnọdụ mmeghachi omume dị nro, dị mfe ịkwalite mmepụta, ma nwee ezigbo uru ngwa bara uru.
Jiri
A na-eji Tobisostat agwọ ọrịa hyperuricemia na-adịghị ala ala nke gout. E jiri ya tụnyere ọgwụ ọdịnala nke allopurinol (analog purine), ọ gaghị emetụta purine na pyridine metabolism na ọrụ enzyme, ọ na-ebelata uric acid Mmetụta dị ike karị, ọ dịghị nnukwu nchịkwa ugboro ugboro achọrọ, na nchekwa dị mma. Methyl 2-cyano-4-pyridine carboxylate bụ ihe dị mkpa akụrụngwa maka njikọ nke Tobiso.
