Mitotan (CAS # 53-19-0)

Ngwongwo kemịkalụ:

Usoro ihe omimi	C14H10Cl4
Molar Mass	320.04
Njupụta	1.3118 (atụmatụ siri ike)
Ebe Na-agbaze	77-78C (ọkụ)
Ebe Boling	405.59°C (atụmatụ siri ike)
Mmiri Solubility	<0.1 g/100 ml na 24ºC
Solubility	DMSO: soluble20mg/ml, doro anya
Ọdịdị	ntụ ntụ
Agba	na-acha ọcha ka agba aja aja
Merck	13,6237 / 13,6237
BRN	2056007
Ọnọdụ Nchekwa	Ikuku ikuku, Okpomọkụ ụlọ
Ntụgharị uche	1.6000 (atụmatụ)
Njirimara anụ ahụ na kemịkalụ	Ebe mgbaze 76-78°C mmiri soluble <0.1g/100 ml na 24°C
Jiri	Ngwaahịa a bụ naanị maka nyocha sayensị na agaghị eji ya maka ebumnuche ndị ọzọ.
Ọmụmụ in vitro	Na mouse TalphaT1 cell line, Mitotane na-egbochi nkwupụta na nzuzo nke TSH, na-egbochi nzaghachi nke TSH na TRH, ma na-ebelata ike cell, ma na-ebute apoptosis. Na pituitary TSH-na-ezobe mkpụrụ ndụ òké, Mitotane adịghị egbochi homonụ thyroid, kama ọ na-ebelata ọrụ nzuzo na ndụ cell. Mitotane na-ebute necrosis cortical adrenal, mmebi akpụkpọ anụ mitochondrial, na njikọ na-enweghị ike ịgbagha na protein CYP. Mitotane (10-40 μm) gbochiri basal na nzuzo cortisol na-akpata caMP mana emeghị ka mkpụrụ ndụ nwụọ. Mitotane gosipụtara mmetụta mgbochi na basal STAR na protein P450scc. Mitotane (40 μm) belatara ọkwa mRNA nke STAR, CYP11A1 na cyp21 nke ukwuu. Mitotane (40 μm) fọrọ nke nta ka ọ kwụsị kpamkpam ntinye nke STAR, CYP11A1, CYP17, na CYP21 mRNA site na adenosine 8-bromo-cyclic phosphate. N'ime usoro S nke mkpụrụ ndụ H295R, nchikota Mitotane na gemcitabine gosipụtara mmegide ma na-egbochi mgbochi gemcitabine na-eme ka ọ bụrụ ihe na-eme ka ọ dị na okirikiri.
Na vivo ọmụmụ	N'ime oke, Mitotane (60 mg / kg) belatara nke ukwuu mitochondrial adrenal na microsomal "P-450" na protein microsomal site na 34%,55% na 35%.

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Nkọwa ngwaahịa

Mkpado ngwaahịa

Akara egwu	Xn - na-emerụ ahụ
Koodu ihe egwu	40 - Ihe akaebe dị oke nke mmetụta carcinogenic
Nkọwapụta nchekwa	36/37 - Yiri uwe nchebe kwesịrị ekwesị na uwe aka.
NJ UN	3249
WGK Germany	3
RTECS	KH7880000
Koodu HS	2903990002
Klas Hazard	6.1 (b)
Otu nkwakọ ngwaahịa	III

Okwu mmalite

Mitotane bụ ngwakọta organic nke nwere aha kemịkal N, N'-methylene diphenylamine. Ihe na-esonụ bụ mmalite nke akụrụngwa, ojiji, ụzọ nkwadebe na ozi nchekwa nke mitotane:

Ogo:

- Mitotane bụ kristal siri ike na-enweghị agba nke na-agbaze na ihe mgbaze organic dị ka ethanol, ether, na chloroform.

- Mitotane nwere isi ísì siri ike.

Jiri:

A na-ejikarị Mitotane eme ihe maka njikọta mmeghachi omume na njikọ organic ma a na-ejikarị ya dị ka reagent na ihe na-akpali akpali.

- Ọ nwere ike isonye na mmeghachi omume kemịkalụ dị iche iche, dị ka njikọ nke alkynes, alkylation nke ogige aromatic, wdg.

Usoro:

- Enwere ike ịmepụta Mitotane site na mmeghachi omume nzọụkwụ abụọ. Formaldehyde na-emeghachi omume na diphenylamine n'okpuru ọnọdụ alkaline iji mepụta N-formaldehyde diphenylamine. Mgbe ahụ, site na pyrolysis ma ọ bụ mmeghachi omume oxidation a na-achịkwa, a na-atụgharị ya na mitotane.

Ozi nchekwa:

- Mitotane bụ ihe na-akpasu iwe na ekwesịghị ịbanye na akpụkpọ ahụ na anya kpọmkwem. Ekwesịrị iyi ihe nchekwa kwesịrị ekwesị dị ka uwe, enyo na uwe nchebe mgbe ị na-arụ ọrụ.

- Mgbe ị na-echekwa ma na-edozi, lezie anya ka ị mechie ma chebe site na ọkụ ka ịzenarị ikuku na mmiri mmiri.

- Mitotane na-emebi na oke okpomọkụ iji mepụta gas na-egbu egbu, zere ikpo ọkụ ma ọ bụ kọntaktị na ihe ndị ọzọ na-ere ọkụ.

- Tụtụ aka na iwu mpaghara ma soro usoro ọrụ nchekwa dị mkpa mgbe ị na-atụfu ha.

Nke gara aga: 4- (4-methoxyphenyl) -1-butanol (CAS # 52244-70-9)

Osote: 2-Chloro-5-aminopyridine (CAS# 5350-93-6)

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