N (alpha) -fmoc-N (epsilon)-(2-chloro-Z) -L-lysine (CAS# 133970-31-7)

Fmoc- (2-chlorobenzyloxycarbonyl) lysine bụ ihe a na-ejikarị amino acid eme ihe nwere ihe ndị a:1. Ọdịdị: ọcha crystalline ntụ ntụ;
2. usoro ihe omimi: C26H24ClNO5;
3. Ọnụ ọgụgụ nke anụ ahụ: 459.92g / mol;
4. Solubility: Soluble na organic solvents dị ka dimethyl sulfoxide (DMSO), dimethyl formamide (DMF), dichloromethane, wdg, insoluble na mmiri;
5. Ebe mgbaze: banyere 170-175 ° C. Ihe bụ isi eji Fmoc- (2-chlorobenzyloxycarbonyl) lysine bụ otu nchekwa na-arụ ọrụ na njikọ nke polypeptides. Enwere ike ịgbalite otu carboxyl ya ka ọ bụrụ ester, nke na-enweta mmeghachi omume condensation na ihe fọdụrụ na amino acid iji mepụta yinye polypeptide. Enwere ike iwepụ otu Fmoc n'ụzọ dị mfe mgbe mmeghachi omume zuru ezu iji kpughee akụkụ amino echedoro.

Usoro nke ịkwadebe Fmoc- (2-chlorobenzyloxycarbonyl) lysine na-agụnye usoro ndị a:

1. na-emeghachi omume lysine na N-hydroxybutyrimide (Pbf) iji webata otu nchebe;
2. na-emeghachi omume lysine-Pbf na mmanya 2-chlorobenzyl iji mepụta Fmoc- (2-chlorobenzyloxycarbonyl) lysine;
3. A na-ewepụta ngwaahịa ahụ na ihe mgbaze kwesịrị ekwesị ma mee ka ọ dị ọcha site na crystallization iji nweta ngwaahịa dị ọcha.

Banyere ozi nchekwa, Fmoc- (2-chlorobenzyloxycarbonyl) lysine bụ reagent kemịkalụ na ekwesịrị ịme usoro nchekwa kwesịrị ekwesị. Ngwa nchebe kwesịrị ekwesị, dị ka uwe ụlọ nyocha, ugogbe anya, na uwe ụlọ nyocha, kwesịrị iyi n'oge nnwale ahụ. Zere iku ume ntụ ntụ ma ọ bụ ihe ngwọta, zere kọntaktị na akpụkpọ ahụ na anya. Ọ bụrụ na kọntaktị na mberede, kpochaa ozugbo na ọtụtụ mmiri ma chọọ enyemaka ahụike. Gbaa mbọ hụ na ejiri ya na gburugburu ụlọ nyocha ma chekwaa nke ọma iji gbochie ihe mberede.