N-Boc-N'-tosyl-D-histidine (CAS# 69541-68-0)

Okwu mmalite

Boc-D-His (Tos) -OH (Boc-D-His (Tos) -OH) bụ ihe kemịkalụ nwere ihe ndị a:

Ọdịdị:

1. Ọdịdị: ọcha siri ike

2. usoro ihe omimi: C21H25N3O6S

3. arọ molekụla: 443.51

4. Ebe mgbaze: ihe dịka 110-115 ° C

Jiri:

Boc-D-His (Tos) -OH na-ejikarị eme ihe na njikọ organic dị ka otu nchebe maka D-histidine (D-His). Isi ojiji ya gụnyere:

1. Na njikọ nke polypeptide, a na-eji ya na-emepụta usoro nke polypeptide nwere otu nchekwa D-histidine.

2. Ejiri ya dị ka onye etiti na ngalaba ọgwụ kemịkalụ maka njikọ nke ogige ebumnuche na-arụ ọrụ nke ndụ.

3. Nhazi na njikọ nke ogige ndị nyocha ọgwụ na nyocha.

Ụzọ nkwadebe:

A na-eme nkwadebe nke Boc-D-His (Tos) -OH site na usoro ndị a:

1. D-histidine (D-His) na-emeghachi omume na p-toluenesulfonyl chloride (p-toluenesulfonyl chloride) iji nye D-histidine p-toluenesulfonyl (D-His-Tos).

2. N'okpuru ọnọdụ alkaline, D-His-Tos na-emeghachi omume na n-butoxycarbonylhydrazine (tert-butyloxycarbonylhydrazide) iji mepụta Boc-D-His (Tos) -OH.

Ozi nchekwa:

Ntụle nchekwa nke Boc-D-His (Tos) -OH nwere oke, mana dịka ihe kemịkalụ, ekwesịrị iburu n'uche nchekwa ndị a:

1. Zere iku ume, kọntaktị na akpụkpọ ahụ na anya. Yiri akụrụngwa nchebe kwesịrị ekwesị, dị ka uwe aka na ugogbe anya.

2. Ekwesịrị ịgbaso usoro nyocha ụlọ nyocha dị mma n'oge a na-eji ya na ọnọdụ ikuku ikuku dị mma kwesịrị ijide n'aka.

3. Chekwaa n'ime akpa mechiri emechi, pụọ na ọkụ na oxidant.

4. Soro ụkpụrụ na ụkpụrụ dị mkpa n'oge nhazi.

Mgbe ị na-eji Boc-D-His(Tos) -OH, biko jide n'aka na ị ga-agbaso ụkpụrụ nchekwa ụlọ nyocha dị mkpa yana ntuziaka ọrụ, wee chekwaa ma jikwaa kemịkalụ nke ọma. Ọ bụrụ na ọ dị mkpa, a na-atụ aro ka ị rụọ ọrụ n'okpuru nduzi nke ndị ọkachamara.