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Nicorandil (CAS# 65141-46-0) Foto egosipụtara
  • Nicorandil (CAS# 65141-46-0) 1

Nicorandil (CAS# 65141-46-0)

Ngwongwo kemịkalụ:

Usoro ihe omimi C8H9N3O4
Molar Mass 211.17
Njupụta 1.4271 (ọnụahịa siri ike)
Ebe Na-agbaze 92°C
Ebe Boling 350.85C (atụmatụ siri ike)
Ebe mgbari 230°C
Solubility DMSO:> 10 mg/mL. Soluble na methanol, ethanol, acetone ma ọ bụ glacial acetic acid, dị ntakịrị soluble na chloroform ma ọ bụ mmiri, ọ fọrọ nke nta ka ọ ghara ịsolu na ether ma ọ bụ benzene.
Uzuoku nrịbama 1.58E-08mmHg na 25°C
Ọdịdị Ọcha na-acha ọcha dị ka crystalline ntụ ntụ
Agba na-acha ọcha na-acha ọcha
Merck 14,6521
Ọnọdụ Nchekwa 2-8 Celsius C
Ntụgharị uche 1.7400 (atụmatụ)
MDL MFCD00186520
Njirimara anụ ahụ na kemịkalụ ntụ ntụ kristal na-acha ọcha, enweghị isi ma ọ bụ ntakịrị ísì, ilu. Soluble na methanol, ethanol, acetone ma ọ bụ acetic acid, ntakịrị soluble na chloroform ma ọ bụ mmiri, ole na ole anaghị agbaze na ether ma ọ bụ benzene. Ebe mgbaze 88.5-93.5 Celsius. Oke nsi LD50 oke (mg/kg):1200-1300 ọnụ, 800-1000 intravenous.
Jiri Maka mgbochi nke ọrịa obi, angina pectoris
Ọmụmụ in vitro Nicorandil (100 mM) mụbara flavoprotein oxidation, mana emetụtaghị akpụkpọ ahụ dị ugbu a, na-eweghachi ọwa mitoK (ATP) na surfaceK (ATP) na mkpokọta dị elu karịa okpukpu iri. Nicorandil na-ebelata ọnwụ cell na ụdị granulation ischemic, mmetụta cardioprotective nke mitoK (ATP) na-egbochi ọwa 5-hydroxydecanoic acid ma ọ bụghị site na eluK (ATP). Mmetụta nke ọwa mgbochi HMR1098. Nicorandil (100 mM) na-egbochi mfu nke TUNEL positivity, cytochrome C translocation, caspase-3 activation, na mitochondrial membrane potential (Delta (Psi)(m)). Nyocha nke mkpụrụ ndụ ndị nwere fluorescence Delta (Psi) (m) - egosi, tetramethylrhodamine ethyl ester (TMRE) site na fluorescence na-arụ ọrụ cell sorter gosiri na, nicorandil na-egbochi Delta (Psi) (m) depolarization n'ụzọ dabere na uche (EC (50). ) ihe dịka 40 mm, saturation 100 mm). N'ime mkpụrụ ndụ abụọ ebugharị, Nicorandil mere ka ọwa 80 pS K na-emeziwanye nke ọma na-adịghị ike. N'ime sel HEK293T, Nicorandil na-arụ ọrụ nke ọma ọwa K(ATP) nwere SUR2B. Nicorandil (100 mM) na-egbochi nke ọma ọnụ ọgụgụ nke mkpụrụ ndụ na TUNEL-positive nuclei na 20 mM h2o2-eme ka caspase-3 rụọ ọrụ. Nleta Nicorandil dabere na-egbochi mfu nke DeltaPsim nke H2O2 kpatara.
Na vivo ọmụmụ Nicorandil (2.5 mg / kg kwa ụbọchị, po) yana Amlodipine (5.0 mg / kg kwa ụbọchị, po) ụbọchị atọ nke ime ihe na-egbochi mgbanwe mgbanwe ma weghachite ọrụ enzyme na ọkwa dị nso na nke oke nkịtị.

Nkọwa ngwaahịa

Mkpado ngwaahịa

Akara egwu Xn - na-emerụ ahụ
Koodu ihe egwu R22 - na-emerụ ma ọ bụrụ na iloro ya
R41 - Ihe ize ndụ nke mmebi anya dị njọ
Nkọwapụta nchekwa S26 - N'ihe banyere kọntaktị na anya, kpochaa ozugbo na ọtụtụ mmiri ma chọọ ndụmọdụ ahụike.
S39 - Yiri anya / nchedo ihu.
WGK Germany 3
RTECS US 4667600
Koodu HS 29333990
Nsi LD50 na oke (mg/kg): 1200-1300 ọnụ; 800-1000 iv (Nagano)

 

Okwu mmalite

Nicolandil, nke a makwaara dị ka nicorandil amine, bụ ngwakọta organic. Ihe na-esonụ bụ mmalite nke njirimara, ojiji, nkwadebe na ozi nchekwa nke nicorandil:

 

Ogo:

- Nicorandil bụ kristal na-enweghị agba nke na-agbaze na mmiri na ihe mgbaze organic.

- Ọ bụ ngwakọta alkaline nke nwere ike imeghachi ya na acid iji mepụta ogige nnu.

- Nicorandil kwụsiri ike na ikuku, mana ọ nwere ike ire ere mgbe okpomoku dị elu.

 

Jiri:

- A pụkwara iji Nicolandil mee ihe na njikọ nke organic synthesis catalysts, photosensitizers, wdg.

 

Usoro:

A na-akwadokarị Nicolandil site na mmeghachi omume nke dimethylamine na ogige 2-carbonyl.

- A na-eme mmeghachi omume n'okpuru ọnọdụ alkaline na mmeghachi omume kpo oku na-eme na ihe mgbaze kwesịrị ekwesị.

 

Ozi nchekwa:

- Nicorandil dịtụ mma maka ụmụ mmadụ n'okpuru ọnọdụ izugbe.

- Otú ọ dị, ekwesịrị ịkpachara anya ka ị ghara imetụ anya, akpụkpọ ahụ, na usoro iku ume.

- Yiri akụrụngwa nchedo nkeonwe kwesịrị ekwesị (PPE) dị ka ugogbe nchekwa, uwe aka na ngwa iku ume.

- Mgbe ị na-eji ma ọ bụ na-echekwa nicorandil, ekwesịrị ịkpachara anya iji zere mgbanye ọkụ na ọnọdụ okpomọkụ dị elu.

 

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